Accession Number : ADA624334


Title :   Value of MRI and DTI as Biomarkers for Classifying Acute Spinal Cord Injury


Descriptive Note : Final rept. 30 Sep 2010-29 Sep 2014


Corporate Author : THOMAS JEFFERSON UNIV PHILADELPHIA PA


Personal Author(s) : Flanders, Adam E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624334.pdf


Report Date : 29 Oct 2014


Pagination or Media Count : 44


Abstract : Purpose: The purpose of this study is to determine if rapid acquisition diffusion tensor imaging (DTI) in conjunction with conventional magnetic resonance imaging (MRI) can be used as a reliable surrogate for assessing extent of neurologic injury and potential for recovery after spinal cord injury (SCI). Methods: 23 SCI patients and 40 control subjects were employed in this study. An MRI/DTI was obtained at initial admission, prior to surgical intervention. Full INSCSCI neurologic evaluation was performed at five time points up to six months after injury. MRI and DTI indices were compared to interval neurologic status and recovery trajectories. Results: Spinal cord hemorrhage and edema on anatomic MRI, and FA, ADC, RD and AD indices derived from DTI data correlate significantly to temporal neurologic parameters that assess extent of neurologic deficit. MRI and DTI indices have a relationship to neurologic recovery parameters. Conclusions: MRI and DTI are valid and objective tools for gauging extent of neurologic injury after SCI and could play a role in helping to forecast potential for recovery in lieu of or as a complementary role to neurologic evaluation.


Descriptors :   *MAGNETIC RESONANCE IMAGING , *SPINAL CORD , *WOUNDS AND INJURIES , CLINICAL MEDICINE , EDEMA , HEMORRHAGE , IMAGE PROCESSING , MOTOR FUNCTION IMPAIRMENT , NERVOUS SYSTEM DISEASES , NEUROLOGY , PARALYSIS , PATIENTS , RECOVERY , RELIABILITY , TENSOR ANALYSIS , TEST AND EVALUATION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE