Accession Number : ADA624310


Title :   Divergent Effects of Dendritic Cells on Pancreatitis


Descriptive Note : Final rept. 15 Aug 2012-14 Aug 2015


Corporate Author : NEW YORK UNIV NY


Personal Author(s) : Miller, George


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624310.pdf


Report Date : Sep 2015


Pagination or Media Count : 37


Abstract : Numbers dendritic cells (DCs) increased 100-fold in pancreata of mice with acute pancreatitis to account for nearly 15% of intrapancreatic leukocytes. Intrapancreatic DCs acquired a distinct immune phenotype in mice with acute pancreatitis; they expressed higher levels of major histocompatibility complex II and CD86 and increased production of interleukin-6, MCP 1, and TNFa. DC over-expansion exacerbated disease. However, DCs were also required for pancreatic viability; the exocrine pancreas died in mice that were depleted of DCs and challenged with caerulein or L-arginine. All mice with pancreatitis that were depleted of DCs died from acinar cell death within 4 days. These data suggest that DC have simultaneous paradoxical pro-inflammatory and protective effects in pancreatitis. Further investigations are warranted.


Descriptors :   *CELLS(BIOLOGY) , *PANCREATITIS , ACTIVATION , INFLAMMATION , MODELS , T LYMPHOCYTES , TISSUES(BIOLOGY)


Subject Categories : Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE