Accession Number : ADA624263


Title :   AltitudeOmics: The Basic Biology of Human Acclimatization to High Altitude. Addendum


Descriptive Note : Final addendum 1 Jan 2011-30 Jun 2014


Corporate Author : COLORADO UNIV AURORA CO


Personal Author(s) : Roach, Robert


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624263.pdf


Report Date : Sep 2014


Pagination or Media Count : 403


Abstract : The goal of this project was to advance high-altitude medical research by discovering the basic molecular mechanisms of acclimatization and de-acclimatization that protect soldiers from high-altitude illness. This was a large, multi-national collaborative project that will pay dividends for years to come. Eight papers are now published, with two more in review, and four more in preparation. Even though funding for the project has terminated, the science is so compelling that scientists around the world will be working for the next year or two to complete reporting on the basic findings. We have made three major breakthroughs in the AltitudeOmics study: 1) We have identified many hundreds of new mechanisms related to acclimatization, 2) including discovery of epigenetic modifications of key hub genes that may be targets suitable for pharmacologic manipulation to improve performance at high altitude and 3) revealed that acclimatization to hypoxia may yield new information about hypoxia-linked diseases.


Descriptors :   *ALTITUDE ACCLIMATIZATION , GENE EXPRESSION , HIGH ALTITUDE , HYPOXIA , PHARMACOLOGY


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE