Accession Number : ADA624177


Title :   Treating Combat Hearing Loss with Atoh1 Gene Therapy


Descriptive Note : Final rept. 1 Oct 2010-31 Mar 2015


Corporate Author : BAYLOR COLL OF MEDICINE HOUSTON TX


Personal Author(s) : Groves, Andrew K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624177.pdf


Report Date : Jun 2015


Pagination or Media Count : 52


Abstract : The goal of the project is to test experimental therapies for hearing loss in transgenic mouse models. We have identified a list of targets of the Atoh1 transcription factor which is a key to regenerating hair cells. We have shown that another candidate pathway, the Notch signaling pathway, is no longer active in the mature animal, and thus is not a viable therapeutic target for hearing loss. We have also generated the means to activate Atoh1 and a supporting factor, Gfi1, in deafened mice to promote hair cell regeneration.


Descriptors :   *AUDITORY DEFECTS , *GENE THERAPY , *REGENERATION(PHYSIOLOGY) , ADENOVIRUSES , CELLS(BIOLOGY) , CULTURES(BIOLOGY) , ENZYMES , EXPERIMENTAL DESIGN , GENE EXPRESSION , GENETICS , INHIBITION , MICE , MILITARY MEDICINE , NEUROPHYSIOLOGY , PROTEINS , RECEPTOR SITES(PHYSIOLOGY) , RESPONSE(BIOLOGY) , RIBONUCLEIC ACIDS , TRANSCRIPTION(GENETICS) , VIABILITY


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE