Accession Number : ADA623485


Title :   A Model of Medical Countermeasures for Organophosphates


Descriptive Note : Technical rept. 15 Apr 2010-14 Apr 2013


Corporate Author : APPLIED RESEARCH ASSOCIATES INC ARLINGTON VA


Personal Author(s) : Rodriguez, Jason ; McClellan, Gene E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a623485.pdf


Report Date : Oct 2015


Pagination or Media Count : 75


Abstract : This paper describes a toxicokinetic/dynamic model of inhaled, intravenous, and percutaneous exposure to several organophosphates (OPs). The model predicts the efficacy of medical countermeasures via a pharmacokinetic/dynamic model of oxime, anticholinergic, anticonvulsant, and bioscavenger treatment regimens.


Descriptors :   *COUNTERMEASURES , *EXPOSURE(PHYSIOLOGY) , *ORGANOPHOSPHATES , *PHARMACOKINETICS , ACETYLCHOLINESTERASE , ANTICONVULSANTS , DOSAGE , DYNAMICS , GB AGENT , INGESTION(PHYSIOLOGY) , INHALATION , INHIBITION , MATHEMATICAL MODELS , MORTALITY RATE , NEUROTRANSMITTERS , OXIMES , PROBABILITY , RECEPTOR SITES(PHYSIOLOGY) , SKIN(ANATOMY) , STIMULATION(PHYSIOLOGY) , TOXICOLOGY , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Toxicology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE