Accession Number : ADA623454


Title :   VRPI Temporal Progression of Closed Globe Injury from Blast Exposure


Descriptive Note : Annual rept. 1 Sep 2014 30 Aug 2015


Corporate Author : UTAH UNIV SALT LAKE CITY


Personal Author(s) : Coats, Brittany ; Shedd, Daniel


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a623454.pdf


Report Date : Sep 2015


Pagination or Media Count : 33


Abstract : The purpose of this grant is to investigate the temporal progression of eye injury from blast exposure and identify early predictors of visual dysfunction. The studies performed in the previous year have shown that blast exposure (approx. 225 kPa magnitude) in a rat model leads to time-dependent ocular pathology changes over the course of eight weeks. Specifically, we have found that the behaviorally assessed visual acuity of blast exposed animals is significantly degraded following blast exposure. The decrease in visual ability is statistically significant when comparing blast-exposed animals to their baseline, preblast visual ability results. The decrease is also significant when comparing control and blast exposed animals at each time point after exposure. These deficits first become significant at two weeks after blast, and do not resolve by the end of the study. The visual acuity findings appear to be initially attributed to immediate retinal damage following blast exposure, but corneal injury also contributes to vision degradation several weeks after the initial blast exposure. We also found early biomarkers of corneal damage that could lead to treatment opportunities for corneal scarring.


Descriptors :   *BLAST , *EYE DISEASES , BIOMECHANICS , CORNEA , EXPOSURE(PHYSIOLOGY) , RATS , VISUAL ACUITY , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE