Accession Number : ADA623180


Title :   Amelioration de la perfusion des organes vitaux par la valve d'impedance inspiratoire et le concept de pompe respiratoire: rationnel physiologique et application clinique (Improving Vital Organs Perfusion by the Respiratory Pump: Physiology and Clinical Use)


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Segal, N ; Yannopoulos, D ; Truchot, J ; Laribi, S ; Plaisance, P ; Convertino, V A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a623180.pdf


Report Date : 01 Sep 2013


Pagination or Media Count : 9


Abstract : Primary function of breathing is to provide gas exchange. Studies of the mechanisms involved in animals and humans provide the physiological underpinnings for the other side of breathing: to increase circulation to the heart and brain. We describe studies that focus on the fundamental relationship between the generation of negative intrathoracic pressure during inspiration through a low-level of resistance created by an impedance threshold device and the physiologic effects of a respiratory pump. A decrease in intrathoracic pressure during inspiration through a fixed resistance resulting in an intrathoracic pressure of -7 cmH2O has multiple physiological benefits including: enhanced venous return, cardiac stroke volume and aortic blood pressure; lower intracranial pressure; resetting of the cardiac baroreflex; elevated cerebral blood flow oscillations and increased tissue blood flow/pressure gradient. The clinical and animal studies support the use of the intrathoracic pump to treat different clinical conditions: hemorrhagic shock, orthostatic hypotension, septic shock, and cardiac arrest.


Descriptors :   *CARDIOPULMONARY RESUSCITATION , CARDIAC ARREST , FRENCH LANGUAGE , HEMORRHAGIC SHOCK , PUMPS , RESPIRATION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE