Accession Number : ADA622987


Title :   A Systems Biology Approach to Heat Stress, Heat Injury and Heat Stroke


Descriptive Note : Journal article


Corporate Author : ARMY CENTER FOR ENVIRONMENTAL HEALTH RESEARCH FORT DETRICK MD


Personal Author(s) : Stallings, Jonathan D ; Ippolito, Danielle L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a622987.pdf


Report Date : Jan 2015


Pagination or Media Count : 13


Abstract : Heat illness is a major source of injury for military populations in both deployed and training settings. Developing tools to help leaders enhance unit performance while reducing the risk of injury is of paramount importance to the military. Here, we review our recent systems biology approaches to heat stress in order to develop a 3-dimensional (3D) realistic thermoregulation model, identify the molecular basis and mediators of injury, and characterize associated biomarkers. We discuss the implications of our work, future directions, and the type of tools necessary to enhance force health protection in the future.


Descriptors :   *HEAT STRESS(PHYSIOLOGY) , *SYSTEMS BIOLOGY , HEAT STROKE , MILITARY FORCES(UNITED STATES) , MODELS , PROTEINS , PROTEOMICS


Subject Categories : Biology
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE