Accession Number : ADA622069


Title :   Host Genes and Resistance/Sensitivity to Military Priority Pathogens


Descriptive Note : Final rept. 1 Jun 2009-31 May 2013


Corporate Author : TENNESSEE UNIV MEMPHIS HEALTH SCIENCE CENTER


Personal Author(s) : Byrne, Gerald I ; Cui, Yan ; Li, Kui ; Lu, Lu ; Miller, Mark A ; Williams, Robert W ; Boon, Adranius ; Bix, Mark ; Marion, Tony


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a622069.pdf


Report Date : Jun 2013


Pagination or Media Count : 254


Abstract : This report provides data from our study of differential susceptibility to DoD priority pathogens (Francisella tularensis (FT), Burkholderia pseudomallei (Bp), Acinetobacter baumannii (Ab), Leishmania major (Lm), SARS, H5N1 avian influenza) using BXD recombinant inbred mice. The FT project identified phenotypes that correlate with differential immune response to pneumonic infections. The Ab project has identified clear phenotypic differences between the innate immune responsiveness of B6 and D2 mice to pulmonary infection. The Bp project has identified QTLs linked with differential susceptibility to pneumonic Bp infection. The SARS project found difference in susceptibility to MA15 virus infection between B6 and D2 mouse strains. The influenza project has identified a significant QTL associated with early production of proinflammatory cytokines on Chr 6. The Lm project has identified two suggestive loci on Chr 12 and 15 regulating parasite burden. The mouse genomics core generated datasets for different mouse strains (available on www.genenetwork.org). The Bioinformatics (Modeling core) analyzed biological data from projects using Bayesian network analysis and created a Bayesian Network Webserver. The Chlamydia genetic studies in BXD mice was used as the prototype model. The bioinformatics core used this model to develop and integrate the algorithms for testing pathways underlying host responses to pathogen infections.


Descriptors :   *GENES , *INFECTIOUS DISEASES , *RESISTANCE(BIOLOGY) , ALGORITHMS , CYTOKINES , FRANCISCELLA TULARENSIS , HOSTS(BIOLOGY) , INFLUENZA , LEISHMANIA , MICE


Subject Categories : Genetic Engineering and Molecular Biology
      Biology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE