Accession Number : ADA621821


Title :   Stem Cell Therapy for Healing Wounded Skin and Soft Tissues


Descriptive Note : Final rept. 15 Jun 2010-14 Dec 2013


Corporate Author : GENEVA FOUNDATION TACOMA WA


Personal Author(s) : Leung, Kai P ; Hong, S K ; Mustoe, T A ; Hale, R G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a621821.pdf


Report Date : Mar 2014


Pagination or Media Count : 57


Abstract : Exogenously applied stem cells can integrate into wounds, and if properly directed to regenerate tissue rather than to rapidly restore the barrier function, should be able to regenerate tissue for improved wound healing. We hypothesize that when applied topically to wounds, adult, adipose-derived mesenchymal stem cells that are directed toward tissue regeneration can reduce inflammation, increase angiogenesis, reduce scarring, and improve the restoration of skin functions. The goal of the proposed research is to define the function of stem cells alone or in atrix to promote healing by regeneration to improve wound repair outcomes.


Descriptors :   *STEM CELLS , CYTOKINES , HEALING , REGENERATION(PHYSIOLOGY) , SOFT TISSUES , THERAPY , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE