Accession Number : ADA621711


Title :   Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-induced Mild Traumatic Brain Injury


Descriptive Note : Annual rept. 1 Mar 2014-28 Feb 2015


Corporate Author : GENEVA FOUNDATION TACOMA WA


Personal Author(s) : Long, Joseph


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a621711.pdf


Report Date : Mar 2015


Pagination or Media Count : 50


Abstract : We hypothesize that the biomechanical perturbations of the brain that yield blast-induced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure (BOP) (i.e. primary blast) and head acceleration and/or impact (i.e. tertiary blast). The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.


Descriptors :   *BIOMECHANICS , *BLAST , *TRAUMATIC BRAIN INJURIES , CELLS(BIOLOGY) , ELECTROPHYSIOLOGY , EXPERIMENTAL DESIGN , EXPOSURE(PHYSIOLOGY) , IMPACT , INFLAMMATION , MILITARY MEDICINE , NEURAL NETS , NEUROLOGY , OVERPRESSURE , PERTURBATIONS , PHYSIOLOGICAL EFFECTS , RESPONSE(BIOLOGY) , RODENTS , SHOCK WAVES , TISSUES(BIOLOGY) , TRAUMA


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Weapons Effects(biological)


Distribution Statement : APPROVED FOR PUBLIC RELEASE