Accession Number : ADA621475


Title :   Alternatives to Autograft Evaluated in a Rabbit Segmental Bone Defect


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : McDaniel, Jennifer S ; Pilia, Marcello ; Raut, Vivek ; Ledford, Jeffrey ; Shiels, Stefanie M ; Wenke, Joseph C ; Barnes, Brian ; Rathbone, Christopher R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a621475.pdf


Report Date : 09 Jul 2015


Pagination or Media Count : 8


Abstract : Purpose This study was designed to identify strategies for treating bone defects that can be completed on the day of surgery. Methods Forty New Zealand white rabbits with unilateral rabbit radius segmental defects (15 mm) were treated with commercially available scaffolds containing either demineralised bone matrix (DBM) or a collagen/beta-tricalcium phosphate composite (Col: -TCP); each scaffold was combined with either bone marrow aspirate (BMA) or concentrated BMA (cBMA). Bone regeneration was assessed through radiographic and histological analyses. Results The concentration of nucleated cells, colony-forming unit-fibroblasts and platelets were increased and haematocrit concentration decreased in cBMA as compared to BMA (p0.05). Radiographic analyses of bone formation and defect bridging demonstrated significantly greater bone regeneration in the defects treated with DBM grafts as compared to Col: -TCP grafts. The healing of bones treated with Col: - TCP was improved when augmented with cBMA. Conclusions Scaffolds containing either DBM or Col: -TCP with BMA or cBMA are effective same-day strategies available to clinicians for the treatment of bone defects; the latter scaffold may be more effective if combined with cBMA.


Descriptors :   *BONES , *SURGICAL TRANSPLANTATION , BONE MARROW , CALCIUM , PHOSPHATES , RABBITS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE