Accession Number : ADA621294


Title :   A SOF Damage Control Resuscitation Cocktail


Descriptive Note : Annual rept. 15 Apr 2014-14 Apr 2015


Corporate Author : WASHINGTON UNIV SEATTLE


Personal Author(s) : White, Nathan J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a621294.pdf


Report Date : May 2015


Pagination or Media Count : 8


Abstract : The goal of this project is to develop a new damage control resuscitation (DCR) cocktail for use by SOF's that is capable of improving survival from polytrauma in austere settings. The cocktail components include Hextend for volume resuscitation and tissue perfusion, fibrinogen concentrate for hemostasis, and tranexamic acid for hemostasis. These components are tested in a combat-relevant swine polytrauma model of hemorrhagic shock with traumatic brain injury, free internal bleeding from an aortic tear, and femur fracture. Model development and validation, and objective 1 and 2 have been initiated in year 1 with an official project start date of April 15, 2014. The project has met with one primary scientific hurdle which has been overcome by adding vasopressin to the model to encourage more bleeding. We expect completion of this project to be on time and within budget.


Descriptors :   *BLOOD COAGULATION , *DAMAGE CONTROL , *FIBRINOGEN , *RESUSCITATION , BONE FRACTURES , CARDIOVASCULAR SYSTEM , CLINICAL MEDICINE , DOSAGE , HEMORRHAGIC SHOCK , PERFUSION , PHYSIOLOGICAL EFFECTS , RESPONSE(BIOLOGY) , STRESS(PHYSIOLOGY) , SURVIVAL(GENERAL) , SWINE , TISSUES(BIOLOGY) , TRAUMATIC BRAIN INJURIES , WOUNDS AND INJURIES


Subject Categories : Biochemistry
      Medicine and Medical Research
      Stress Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE