Accession Number : ADA621182


Title :   Effects of Pharmacologic and Genetic Inhibition of Alk on Cognitive Impairments in NF1 Mutant Mice


Descriptive Note : Annual rept. 1 Jun 2014-31 May 2015


Corporate Author : OREGON HEALTH AND SCIENCE UNIV PORTLAND


Personal Author(s) : Raber, Jacob ; Marzulla, Tessa


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a621182.pdf


Report Date : Jun 2015


Pagination or Media Count : 17


Abstract : We studied the expression of Alk and the effects of Alk mutations on learning and memory in mice. Concordant with studies in flies, we found enhanced retention of spatial memory in Alk mutant mice. Retention of spatial memory is a hippocampal dependent function. We also demonstrated expression of Alk throughout the adult murine hippocampus. The behavioral phenotype of Alk mutant mice is the opposite of the behavioral phenotype of Nf1 mutant mice. We hypothesize that the genetic interaction between Alk and Nf1 in mice is similar to the behavioral phenotypes of Alk and Nf1 mutations in flies and that pharmacologic or genetic inhibition of Alk in Nf1 mutant mice will attenuate or even rescue learning impairments in mice. We describe the breeding data for the genetic study and the behavioral data so far for the genetic study and pharmacological study. The behavioral data are very encouraging and support our hypothesis. While slower due to the breeding effort involved, this project is going extremely well.


Descriptors :   *BRAIN , *COGNITIVE IMPAIRMENT , *GENE EXPRESSION , BEHAVIOR , CHROMOSOMES , ELECTROPHYSIOLOGY , HIPPOCAMPUS , INHIBITION , KINETICS , LEARNING , LEARNING DISABILITIES , MEMORY(PSYCHOLOGY) , MENTAL ABILITY , MICE , MUTATIONS , NERVOUS SYSTEM , NEUROBIOLOGY , PHARMACOLOGY , PHOSPHORUS TRANSFERASES , RECEPTOR SITES(PHYSIOLOGY) , RETENTION(PSYCHOLOGY) , WINGED INSECTS


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE