Accession Number : ADA620986


Title :   Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice


Descriptive Note : Journal article


Corporate Author : ARMY CENTER FOR ENVIRONMENTAL HEALTH RESEARCH FORT DETRICK MD


Personal Author(s) : Lassance-Soares, Roberta M ; Sood, Subeena ; Chakraborty, Nabarun ; Jhamnani, Sunny ; Aghili, Nima ; Nashin, Hajra ; Hammamieh, Rasha ; Jett, Marti ; Epstein, Stephen E ; Burnett, Mary S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620986.pdf


Report Date : 15 Oct 2014


Pagination or Media Count : 9


Abstract : Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor s cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.


Descriptors :   *BLOOD CIRCULATION , *STRESS(PSYCHOLOGY) , BEHAVIOR , EXTREMITIES , FLOW , ISCHEMIA , MICE , POST TRAUMATIC STRESS DISORDER


Subject Categories : Psychology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE