Accession Number : ADA620529


Title :   Cortical Lesions as Determinants of White Matter Lesion Formation and Cognitive Abnormalities in MS


Descriptive Note : Annual rept. 1 May 2014-20 Apr 2015


Corporate Author : MAYO CLINIC ROCHESTER MN


Personal Author(s) : Port, John D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620529.pdf


Report Date : May 2015


Pagination or Media Count : 9


Abstract : This study evaluates for the presence of connectivity between cortical lesions and white matter lesions in patients with MS. During the report period, we have statistically documented this connectivity, presented our findings at 2 national meetings, and have submitted a paper to Neurology. Using one of our novel imaging sequences, we have documented a characteristic halo around larger MS lesions that seems specific to MS. We are currently collecting and analyzing data from our positive control cohort to confirm that this finding is not noted with other types of white matter pathology. Both lesion connectivity and MS lesion halos may serve as novel new imaging biomarkers for the disease. We have explored automated cortical lesion detection. We have begun preparation for tract-based and normal-appearing white matter analysis using DTI derived metrics as well as image intensity ratios.


Descriptors :   *LESIONS , *NERVOUS SYSTEM DISEASES , ABNORMALITIES , BIOLOGICAL DETECTION , CENTRAL NERVOUS SYSTEM , CEREBRAL CORTEX , CLINICAL MEDICINE , COGNITION , ELECTROPHYSIOLOGY , EXPERIMENTAL DESIGN , MAGNETIC RESONANCE IMAGING , NEURAL NETS , NEUROLOGY , PATHOPHYSIOLOGY , PATIENTS , RESPONSE(BIOLOGY) , SIGNAL PROCESSING , TRACER STUDIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE