Accession Number : ADA620383


Title :   Muscle-bone Interactions During Fracture Healing


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Davis, K M ; Griffin, K S ; Chu, T-M G ; Wenke, J C ; Corona, B T ; McKinley, T O ; Kacena, M A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620383.pdf


Report Date : 01 Mar 2015


Pagination or Media Count : 10


Abstract : Although it is generally accepted that the rate and strength of fracture healing is intimately linked to the integrity of the surrounding soft tissues, the contribution of muscle that has largely been viewed as vascular supply for oxygen and nutrient exchange. However, more is becoming known about the cellular and paracrine contributions of muscle to the fracture healing process. Research has shown that muscle is capable of supplying osteoprogenitor cells in cases where the periosteum is insufficient, and the muscular osteoprogenitors possess similar osteogenic potential to those derived from the periosteum. Muscle's secrotome includes proteins capable of inhibiting or enhancing osteogenesis and myogenesis following musculoskeletal injury and can be garnered for therapeutic use in patients with traumatic musculoskeletal injuries. In this review, we will highlight the current knowledge on muscle-bone interaction in the context of fracture healing as well as concisely present the current models to study such interactions.


Descriptors :   *BONE FRACTURES , *MUSCULOSKELETAL SYSTEM , *OSTEOGENESIS , *REGENERATION(PHYSIOLOGY) , ANGIOGENESIS , CLINICAL MEDICINE , ENDOTHELIUM , GROWTH(PHYSIOLOGY) , HEALING , INFLAMMATION , INSULIN , INTERACTIONS , MORPHOLOGY , MUSCLES , NUTRIENTS , ORTHOPEDICS , OXYGEN , PATIENTS , PROTEINS , SOFT TISSUES , STEM CELLS , STRENGTH(GENERAL) , SURGEONS , THERAPY , TRAUMATIC SHOCK , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE