Accession Number : ADA620381


Title :   An Autologous Muscle Tissue Expansion Approach for the Treatment of Volumetric Muscle Loss


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Ward, Catherine L ; Ji, Lisa ; Corona, Benjamin T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620381.pdf


Report Date : 01 Jul 2015


Pagination or Media Count : 12


Abstract : Volumetric muscle loss (VML) is a hallmark of orthopedic trauma with no current standard of care. As a potential therapy for some VML indications, autologous minced muscle grafts (1mm 3 pieces of muscle) are effective in promoting remarkable denovo fiber regeneration. But they require ample donor muscle tissue and therefore may be limited in their application for large clinical VML. Here, we tested the hypothesis that autologous minced grafts may be volume expanded in a collagen hydrogel, allowing for the use of lesser autologous muscle while maintaining regenerative and functional efficacy. The results of the study indicate that 50% (but not 75%) less minced graft tissue suspended in a collagen hydrogel promoted a functional improvement similar to that of a 100% minced graft repair. However, approximately half of the number of fibers regenerated denovo with 50% graft repair. Moreover, the fibers that regenerated had a smaller cross-sectional area. These findings support the concept of using autologous minced grafts for the regeneration of muscle tissue after VML, but indicate the need to identify optimal carrier materials for expansion.


Descriptors :   *BIOENGINEERING , *MUSCULOSKELETAL SYSTEM , *REGENERATION(PHYSIOLOGY) , *SURGICAL TRANSPLANTATION , *TISSUES(BIOLOGY) , BIOMATERIALS , CELLS(BIOLOGY) , CLINICAL MEDICINE , COLLAGEN , EXPERIMENTAL DESIGN , HISTOLOGY , IMMUNOLOGY , IN VIVO ANALYSIS , MORPHOLOGY , MUSCLE FIBERS , NEUROLOGY , OPTIMIZATION , ORTHOPEDICS , PHYSIOLOGICAL EFFECTS , RATS , STATISTICAL ANALYSIS , TRAUMA , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Biomedical Instrumentation and Bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE