Accession Number : ADA620336


Title :   Recipient Wound Bed Characteristics Affect Scarring and Skin Graft Contraction


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Rose, Lloyd F ; Wu, Jesse C ; Carlsson, Anders H ; Tucker, David I ; Leung, Kai P ; Chan, Rodney K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620336.pdf


Report Date : 13 Feb 2015


Pagination or Media Count : 11


Abstract : The use of autograft skin is essential in the treatment of full thickness burns and large cutaneous defects. Both autograft thickness and condition of the wound bed modulate aesthetic and functional outcomes. Thicker autografts contract less and maintain greater functionality as the scar matures. The presence of hypodermis can also positively affect the eventual appearance and functionality of the wound site by modulating contraction and alleviating inflammation and cellular stress responses. In this study, we characterize wound-site physical and cellular characteristics following split-thickness skin grafting onto hypodermis vs. onto fascia. Compared to autografts grafted onto fascia, identical thickness autografts grafted onto fat demonstrated reduced contraction, enhanced mobility and vascularity, and reduced topographical variability. Grafts onto fat also showed reduced levels of myofibroblasts and leukocytic infiltration. The status of the wound bed prior to engraftment is an important contributor of skin quality outcome. The presence of hypodermis is associated with improved functional and aesthetic qualities of split thickness skin grafts, which are correlated with reduced presence of myofibroblasts and leukocytic infiltration.


Descriptors :   *SKIN GRAFTS , CONTRACTION , INFLAMMATION , SKIN DISEASES , SURGICAL TRANSPLANTATION , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE