Accession Number : ADA620301


Title :   Combat Veterans with PTSD after Mild TBI Exhibit Greater ERPs from Posterior-medial Cortical Areas While Appraising Facial Features


Descriptive Note : Journal article


Corporate Author : NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA


Personal Author(s) : Shu, I-Wei ; Onton, Julie A ; Prabhakar, Nitin ; O'Connell, Ryan M ; Simmons, Alan N ; Matthews, Scott C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a620301.pdf


Report Date : Jan 2014


Pagination or Media Count : 9


Abstract : Posttraumatic stress disorder (PTSD) worsens prognosis following mild traumatic brain injury (mTBI). Combat personnel with histories of mTBI exhibit abnormal activation of distributed brain networks including emotion processing and default mode networks. How developing PTSD further affects these abnormalities has not been directly examined. We recorded electroencephalography in combat veterans with histories of mTBI, but without active PTSD (mTBI only, n=16) and combat veterans who developed PTSD after mTBI (mTBI+PTSD, n=16) during the Reading the Mind in the Eyes Test (RMET), a validated test of empathy requiring emotional appraisal of facial features. Task-related event related potentials (ERPs) were identified, decomposed using independent component analysis (ICA) and localized anatomically using dipole modeling. We observed larger emotional face processing ERPs in veterans with mTBI+PTSD, including greater N300 negativity. Furthermore, greater N300 negativity correlated with greater PTSD severity, especially avoidance/numbing and hyper arousal symptom clusters. This correlation was dependent on contributions from the precuneus and posterior cingulate cortex (PCC). Our results support a model where, in combat veterans with histories of mTBI, larger ERPs from over- active posterior medial cortical areas may be specific to PTSD, and is likely related to negative self-referential activity.


Descriptors :   *POST TRAUMATIC STRESS DISORDER , *TRAUMATIC BRAIN INJURIES , *VETERANS(MILITARY PERSONNEL) , ELECTROENCEPHALOGRAPHY


Subject Categories : Psychology
      Medicine and Medical Research
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE