Accession Number : ADA618963


Title :   In Vivo Performance of Bilayer Hydroxyapatite Scaffolds for Bone Tissue Regeneration in the Rabbit Radius


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Guda, Teja ; Walker, John A ; Pollot, Beth E ; Appleford, Mark R ; Oh, Sunho ; Ong, Joo L ; Wenke, Joseph C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a618963.pdf


Report Date : 02 Feb 2011


Pagination or Media Count : 12


Abstract : The objective of this study was to investigate the in vivo biomechanical performance of bone defects implanted with novel bilayer hydroxyapatite (HAp) scaffolds that mimic the cortical and cancellous organization of bone. The scaffolds maintained architectural continuity in a rabbit radius segmental defect model and were compared to an untreated defect group (negative control) and autologous bone grafts (positive control). Micro-CT evaluations indicated total bone and scaffold volume in the experimental group was significantly greater than the defect group but lesser than the autologous bone graft treatment. The flexural toughness of the scaffold and the autograft groups was significantly greater than the flexural toughness of the defect group. Interestingly, the absolute density of the bone mineral as well as calcium to phosphorus (Ca/P) ratio in that mineral for the scaffold and autograft contralateral bones was significantly higher than those for the defect contralaterals suggesting that the scaffolds contributed to calcium homeostasis. It was concluded from this study that new bone regenerated in the bilayer HAp scaffolds was comparable to the empty defects and while the HAp scaffolds provided significant increase in modulus when compared to empty defect and their flexural toughness was comparable to autografts after 8 weeks of implantation.


Descriptors :   *BONES , *REGENERATION(PHYSIOLOGY) , *TISSUES(BIOLOGY) , BIOMECHANICS , COMPUTERIZED TOMOGRAPHY , DEFECTS(MATERIALS) , DENSITY , FLEXIBLE MATERIALS , HISTOLOGY , IN VIVO ANALYSIS , LAYERS , MINERALS , PERFORMANCE(ENGINEERING) , POROSITY , RABBITS , RADIOGRAPHY , TOUGHNESS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Miscellaneous Materials
      Mechanics


Distribution Statement : APPROVED FOR PUBLIC RELEASE