Accession Number : ADA618678


Title :   Glasgow Coma Scale Scores, Early Opioids, and 4-year Psychological Outcomes among Combat Amputees


Descriptive Note : Journal article


Corporate Author : NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA


Personal Author(s) : Melcer, Ted ; Walker, Jay ; Bhatnagar, Vibha ; Richard, Erin ; Han, Peggy ; Sechriest, II, V F ; Lebedda, Martin ; Quinn, Kimberly ; Galarneau, Michael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a618678.pdf


Report Date : Jan 2014


Pagination or Media Count : 16


Abstract : Morphine and fentanyl are frequently used for analgesia after trauma, but there is debate over the advantages and disadvantages of these opioids. Among combat amputees, intravenous (IV) morphine (vs IV fentanyl) after injury was associated with reduced likelihood of posttraumatic stress disorder (PTSD). The previous results were based on military health diagnoses over 2 yr post-injury. The present study followed psychological diagnoses of patients with amputation for 4 yr using military and Department of Veterans Affairs health data. In theater combat casualty records (n = 145) documented Glasgow Coma Scale (GCS) scores and/or morphine, fentanyl, or no opioid treatment within hours of injury. We found that (1) GCS scores were not significantly associated with PTSD; (2) longitudinal modeling using four (yearly) time points showed significantly reduced odds of PTSD for patients treated with morphine (vs fentanyl) across years (adjusted odds ratio = 0.40; 95% confidence interval = 0.17-0.94); (3) reduced PTSD prevalence for morphine (vs IV fentanyl; morphine = 25%, fentanyl = 59%, p less than 0.05) was significant, specifically among patients with traumatic brain injury during the first 2 yr post-injury; and (4) PTSD prevalence, but not other disorders (e.g., mood), increased between year 1 (PTSD = 18%) and years 2 through 4 post-injury (PTSD range = 30%-32%).


Descriptors :   *AMPUTEES , *MILITARY PERSONNEL , *MORPHINE , *POST TRAUMATIC STRESS DISORDER , ANALGESIA , CASUALTIES , COMA(PHYSIOLOGY) , CONFIDENCE LEVEL , DATA ACQUISITION , DEMOGRAPHY , INGESTION(PHYSIOLOGY) , MENTAL HEALTH , PATIENTS , STATISTICAL ANALYSIS , STRESS(PSYCHOLOGY) , THEATER LEVEL OPERATIONS , TRAUMATIC BRAIN INJURIES , WOUNDS AND INJURIES


Subject Categories : Psychology
      Pharmacology
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE