Accession Number : ADA618504


Title :   Regenerative Medicine and Restoration of Joint Function


Descriptive Note : Final rept. 27 Sep 2010-26 Sep 2014


Corporate Author : MOUNT SINAI HOSPITAL TORONTO (ONTARIO) SAMUEL LUNENFIELD RESEARCH INST


Personal Author(s) : Kandel, Rita


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a618504.pdf


Report Date : Dec 2014


Pagination or Media Count : 147


Abstract : Currently amputation, arthrodesis (joint fusion), or joint replacement are used to treat a joint with an intra-articular fracture or destroyed by a combat injury. Generation of personalized, anatomically shaped biological implants formed using techniques of regenerative medicine in conjunction with biodegradable biomaterial structures to restore a damaged articular joint surface to normal tissue structure, form and function is one way to overcome the limitations associated with current treatment methods. The aims of this study are to: 1) identify the parameters that generate anatomically shaped bone substitutes of optimal composition and structure with an articulating profile. 2) to develop a source of chondrocytes that can generate sufficient amounts of a cartilage layer to cover the bone substitute; and 3) to evaluate the structures formed in a preclinical model. The ongoing studies will further our understanding of the regulation of cell differentiation to chondrocytes and the bone substitute properties required to form a biological joint replacement.


Descriptors :   *JOINTS(ANATOMY) , *REGENERATIVE MEDICINE , AMPUTATION , BIODETERIORATION , BIOLOGY , BONES , CARTILAGE , CLINICAL MEDICINE , IMPLANTATION , LAYERS , LIMITATIONS , MEDICINE , MODELS , SUBSTITUTES , TISSUES(BIOLOGY) , WARFARE , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE