Accession Number : ADA618417


Title :   Expression of Proteins Involved in Epithelial-Mesenchymal Transition as Predictors of Metastasis and Survival in Breast Cancer Patients


Descriptive Note : Final summary rept. 1 Nov 2010-31 Oct 2014


Corporate Author : HEALTH RESEARCH INC BUFFALO NY


Personal Author(s) : Roberts, Michelle ; Bshara, Wiam ; Higgins, Michael ; Freudenheim, Jo ; Das, Gokul ; Miller, Austin ; Ambrosone, Christine


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a618417.pdf


Report Date : Jan 2015


Pagination or Media Count : 31


Abstract : The purpose of this research is to investigate protein expression and promoter region DNA methylation status of six genes involved in epithelial-mesenchymal transition in relation to breast cancer lymph node metastasis, recurrence, and survival. Breast tumor tissue has been retrospectively identified from the Pathology Resource and immunohistochemical staining for all proteins has been completed. Scoring and analysis of IHC assays is ongoing. FFPE tissue cores for a subset of the IHC-stained tissues have been procured for isolation of DNA and methylation assay.


Descriptors :   *BREAST CANCER , *METASTASIS , ASSAYING , BIOLOGICAL STAINS , CLINICAL MEDICINE , DEOXYRIBONUCLEIC ACIDS , DIAGNOSIS(MEDICINE) , EPIDEMIOLOGY , EPITHELIUM , HISTOCHEMISTRY , IMMUNOLOGY , LYMPH , MAMMARY GLANDS , METHYLATION , NEOPLASMS , PROTEINS , SURVIVAL(GENERAL) , TISSUES(BIOLOGY)


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE