Accession Number : ADA617726


Title :   Competitive Endogenous RNAs in Prostate Cancer


Descriptive Note : Final rept. 1 Nov 2013-31 Oct 2014


Corporate Author : MISSISSIPPI UNIV MEDICAL CENTER JACKSON


Personal Author(s) : Mo, Yin-Yuan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a617726.pdf


Report Date : Jan 2015


Pagination or Media Count : 9


Abstract : The human genome actively transcribes a large amount of non-coding genes, including microRNA and long noncoding RNAs (lncRNAs). Compared to well-known microRNAs, lncRNAs are poorly characterized. However, emerging evidence suggests that lncRNAs may be dysregulated in prostate cancer, but their role in prostate cancer remains elusive. We hypothesize that prostate cancer may exploit this mechanism to promote tumor progression and metastasis, and therapy resistance. Thus, overall goal of this application is to determine whether lncRNAs function as competitive endogenous RNAs (CeRNAs) which are capable of sequestering microRNAs to regulate RNA transcripts. A better understanding of how microRNAs are dysregulated in prostate cancer may help biomarker discovery, ultimately developing a better strategy for prostate cancer treatment.


Descriptors :   *GENOME , *PROSTATE CANCER , *RIBONUCLEIC ACIDS , CLINICAL MEDICINE , GENES , NEOPLASMS , PROTEINS , RECEPTOR SITES(PHYSIOLOGY) , RESISTANCE(BIOLOGY) , SYNTHESIS(CHEMISTRY) , THERAPY , TISSUES(BIOLOGY) , VITAMIN B COMPLEX


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE