Accession Number : ADA614921


Title :   Evidence for the Inhibition of Dengue Virus Binding in the Presence of Silver Nanoparticles


Descriptive Note : Master's thesis


Corporate Author : AIR FORCE INSTITUTE OF TECHNOLOGY WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT/DEPT OF ENGINEERING PHYSICS


Personal Author(s) : Williams, Kelley J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a614921.pdf


Report Date : 26 Mar 2015


Pagination or Media Count : 60


Abstract : Dengue is an emerging hemorrhagic fever virus and widely considered the most important arbovirus in the world. Dengue virus (DENV) is a positive-sense RNA virus that exists in 4, potentially 5, antigenic serotypes. Currently, no vaccines or treatments are approved for DENV infections. Unsuccessful vaccine trials open the door for non-traditional treatments such as silver nanoparticles. Silver nanoparticles (AgNP) are known to inhibit viral replication of numerous viruses but have never before been tested for inhibition of dengue virus type 2 (DENV2, ATCC(registered trademark) VR-1584trademark). For the first time, this research presents up to a 96% reduction in DENV2 binding to Vero cells following pretreatment with AgNP (6-10nm, 25(mu)g/mL). These results suggest that similarly to other viruses, DENV2 can be inhibited at the first stage of the virus replication cycle, binding & entry.


Descriptors :   *DENGUE VIRUS , ARBOVIRUSES , CELLS(BIOLOGY) , HEMORRHAGIC FEVERS , INFECTIOUS DISEASES , INHIBITION , MEDICAL RESEARCH , NANOPARTICLES , SILVER , THESES , VACCINES


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE