Accession Number : ADA614386


Title :   Biofilms and Persistent Wound Infections in United States Military Trauma Patients: a Case-control Analysis


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Akers, Kevin S ; Mende, Katrin ; Cheatle, Kristelle A ; Zera, Wendy C ; Yu, Xin ; Beckius, Miriam L ; Aggarwal, Deepak ; Li, Ping ; Sanchez, Carlos J ; Wenke, Joseph C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a614386.pdf


Report Date : 08 Apr 2014


Pagination or Media Count : 12


Abstract : Background: Complex traumatic injuries sustained by military personnel, particularly when involving extremities, often result in infectious complications and substantial morbidity. One factor that may further impair patient recovery is the persistence of infections. Surface-attached microbial communities, known as biofilms, may play a role in hindering the management of infections; however, clinical data associating biofilm formation with persistent or chronic infections are lacking. Therefore, we evaluated the production of bacterial biofilms as a potential risk factor for persistent infections among wounded military personnel. Methods: Bacterial isolates and clinical data from military personnel with deployment-related injuries were collected through the Trauma Infectious Disease Outcomes Study. The study population consisted of patients with diagnosed skin and soft-tissue infections. Cases (wounds with bacterial isolates of the same organism collected 14 days apart) were compared to controls (wounds with non-recurrent bacterial isolates), which were matched by organism and infectious disease syndrome. Potential risk factors for persistent infections, including biofilm formation, were examined in a univariate analysis. Data are expressed as odds ratios (OR; 95% confidence interval [CI]). Results: On a per infected wound basis, 35 cases (representing 25 patients) and 69 controls (representing 60 patients) were identified. Eight patients with multiple wounds were utilized as both cases and controls. Overall, 235 bacterial isolates were tested for biofilm formation in the case control analysis. Biofilm formation was significantly associated with infection persistence (OR: 29.49; CI: 6.24-infinity) in a univariate analysis.


Descriptors :   *INFECTIOUS DISEASES , *WOUNDS AND INJURIES , DEMOGRAPHY , EXTREMITIES , FILMS , MILITARY MEDICINE , MILITARY PERSONNEL , MORBIDITY , RISK , STRAINS(BIOLOGY) , TRAUMA


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE