Accession Number : ADA613999


Title :   Opioid Abuse after TBI


Descriptive Note : Annual rept. 1 Jul 2013-30 Jun 2014


Corporate Author : ALABAMA UNIV IN BIRMINGHAM


Personal Author(s) : Floyd, Candance L ; Nicholson, Katherine L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613999.pdf


Report Date : Jul 2014


Pagination or Media Count : 12


Abstract : The goal of this project is to evaluate the hypothesis that traumatic brain injury induces alterations in the brain s reward circuitry which may make an injured brain more susceptible to the rewarding effects of opioids. We are currently conducting experiments to evaluate the hypothesis that TBI causes changes in the analgesic response to opioids following acute and repeated drug administration. We are also testing the hypothesis that moderate TBI increases the susceptibility for opioid abuse as measured by an alteration in the rewarding properties of oxycodone. We have completed the third year of experimentation and thus far have found that TBI induces changes in oxycodone abuse-related behaviors and may induce alteration in the brain reward, particularly expression of the dopamine receptor subtype 2. All studies are on-going.


Descriptors :   *DRUG ABUSE , *TRAUMATIC BRAIN INJURIES , ANALGESICS , BRAIN , DOPAMINE , RECEPTOR SITES(PHYSIOLOGY) , RESPONSE


Subject Categories : Medicine and Medical Research
      Toxicology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE