Accession Number : ADA613861


Title :   Attractor Signaling Models for Discovery of Combinatorial Therapies


Descriptive Note : Final rept. 15 Aug 2012-14 Aug 2014


Corporate Author : MICHIGAN STATE UNIV EAST LANSING


Personal Author(s) : Piermarocchi, Carlo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613861.pdf


Report Date : Nov 2014


Pagination or Media Count : 43


Abstract : The objective of this project consists in demonstrating that attractor models increase the chances of discovering combinations of many drugs with strong synergistic effects in lung cancer. The approach will be tested using a high throughput screening facility to compare the therapeutic effectiveness of random combinations and combinations predicted to be effective by the model.


Descriptors :   *LUNG CANCER , DRUGS , MATHEMATICAL MODELS , THERAPY


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE