Accession Number : ADA613740


Title :   A Novel Hand-Held Optical Imager with Real-Time Co-Registration Facilities Towards Diagnostic Mammography


Descriptive Note : Annual summary rept. 1 Jan 2009-31 Dec 2011


Corporate Author : FLORIDA INTERNATIONAL UNIV MIAMI


Personal Author(s) : Erickson, Sarah J ; Godavarty, Anuradha


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613740.pdf


Report Date : Jan 2012


Pagination or Media Count : 55


Abstract : Hand-held optical imaging devices using near-infrared (NIR) light are currently developed toward clinical translation of the technology. However, none of the devices developed to date have been used toward 3D tomography since they are not able to coregister the image to the tissue geometry. The objective for the work described herein is the clinical translation of a handheld optical imager with automated coregistration facilities toward 3D tomography. Studies were performed in phantoms, in vitro, and in vivo with healthy female volunteers. A spherical target filled with a fluorescent contrast agent was placed superficially underneath the breast tissue to represent a tumor. Images were collected and coregistered using the hand-held imager. The data from the coregistered image was used to generate a 3D image of the target within the breast tissue. Preliminary studies were carried out to demonstrate 2D diffuse optical imaging with actual breast cancer subjects. The results show for the first time the feasibility of performing 3D tomography in human breast tissue and imaging of human breast cancer in vivo using a hand-held optical imager.


Descriptors :   *BREAST CANCER , *MAMMOGRAPHY , *OPTICAL EQUIPMENT , CLINICAL MEDICINE , DIAGNOSIS(GENERAL) , FACILITIES , FEASIBILITY STUDIES , FEMALES , FLUORESCENCE , HAND HELD , IMAGES , IN VIVO ANALYSIS , MAMMARY GLANDS , NEAR INFRARED RADIATION , OPTICAL IMAGES , TISSUES(BIOLOGY) , TOMOGRAPHY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE