Accession Number : ADA613700

Title :   Stanford Center for Military Photomedicine

Descriptive Note : Final rept. 1 Sep 2010-31 Dec 2013

Corporate Author : STANFORD UNIV CA

Personal Author(s) : Contag, Christopher ; Palanker, Daniel ; Schrizter, Mark

Full Text :

Report Date : 08 Sep 2014

Pagination or Media Count : 12

Abstract : This project was aimed at developing clinically-deployable instrumentation for restoration of sight and hearing, and rapid, high-resolution in vivo imaging. Restoration of sight was accomplished using photovoltaic sub-retinal prosthesis in which photovoltaic arrays (70 micrometer pixel size) restored visual acuity in rats with retinal degeneration to half of normally-sighted controls. In the field of retinal plasticity following ocular injury, we demonstrated closure of the retinal damage zone (under 200 micrometers) and migration/rewiring of photoreceptors. For high-resolution imaging we have miniaturized confocal microscopes to fit into hand-held devices, with wide-field guidance, and have optimized the software to represent data as H&E stained sections--this point-of-care tool can rapidly assess tissue viability for guided debridement. We have also developed a clinically deployable second-harmonic generation microendoscope that reveals specific patterns of tissue and cellular micro-architecture, and visualized sarcomere lengths and twitch contraction dynamics, and abnormalities in individual striated muscle fibers of humans. This tool was further modified for neurotology to visualize the inner ear and guide placement of cochlear implants after blast injury.


Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE