Accession Number : ADA613668


Title :   Normal Coagulation


Descriptive Note : Book chapter


Corporate Author : VERMONT UNIV BURLINGTON


Personal Author(s) : Mann, Kenneth ; Brummel-Ziedins, Kathleen


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613668.pdf


Report Date : 04 Sep 2014


Pagination or Media Count : 31


Abstract : Maintenance life. Blood flow may be lost because of pump failure, leakage of blood, or blood vessel obstruction. The coagulation system has evolved to deal with the last two events by providing qualities that maintain blood in a fluid state within the vasculature. This challenge is met by a three-component system that promotes vascular blood fluidity while anticipating the requirement for blockade of extravascular blood flow. The system involves vascular endothelial cells, blood, and extravascular tissue. These three compartments maintain fluidity or produce an integrated response to attenuate blood leakage by localized clotting at the site of vascular injury, with the dimensions of the response in proportion to the injury.


Descriptors :   *BLOOD COAGULATION , ACTIVATION , BIOCHEMISTRY , BLOOD CIRCULATION , BLOOD PLATELETS , BLOOD PROTEINS , BLOOD VESSELS , CARDIOVASCULAR SYSTEM , CELLS(BIOLOGY) , ENDOTHELIUM , FIBRIN , INHIBITORS , OBSTRUCTION(PHYSIOLOGY) , PUMPS , SURGERY , VITAMIN K


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE