Accession Number : ADA613613


Title :   Assessment of Nanobiotechnology-Targeted siRNA Designed to Inhibit NF-KappaB Classical and Alternative Signaling in Breast Tumor Macrophages


Descriptive Note : Final rept. 1 Jul 2011-30 Jun 2014


Corporate Author : VANDERBILT UNIV NASHVILLE TN


Personal Author(s) : Yull, Fiona


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613613.pdf


Report Date : Jul 2014


Pagination or Media Count : 84


Abstract : Macrophages have been proposed as a potential target for manipulation of the microenvironment in breast cancer because they are potent effectors of the immune system. NF kappaB (NF B) signaling in macrophages contributes to their impact during breast tumorigenesis. Thus, macrophage targeted modulation of NF B has potential as a novel therapeutic approach for breast cancer. NF B signaling is mediated via two major pathways; the canonical/classical pathway and the alternative pathway. Our strategy is designed to develop a nanobiotechnology-based method to target siRNA designed to inhibit NF B classical and alternative signaling specifically to tumor associated macrophages to modulate the tumor microenvironment and to test the therapeutic potential of this approach. In this highly collaborative stufy, we have synthesized and characterized in vitro both mannosylated and untargeted nanoparticles. We have compared the efficiency of transfection of bone marrow derived.


Descriptors :   *BREAST CANCER , *MACROPHAGES , *NEOPLASMS , *RIBONUCLEIC ACIDS , BIOTECHNOLOGY , INHIBITION , NANOPARTICLES , NANOTECHNOLOGY , SIGNALS , TRANSFECTION


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE