Accession Number : ADA613598


Title :   The Role of Platelet-Derived Growth Factor C and Its Splice Variant in Breast Cancer


Descriptive Note : Annual summary rept. 15 Jan 2011 - 14 Jan 2012


Corporate Author : WAYNE STATE UNIV DETROIT MI


Personal Author(s) : Bottrell, Alyssa


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a613598.pdf


Report Date : Feb 2012


Pagination or Media Count : 13


Abstract : The PDGF family consists of four members, PDGF A, B, C, and D. Human breast carcinoma cell lines show increased PDGFC mRNA expression in cell lines with high tumorigenicity and invasive potential. The typical paradigm of growth factors is extracellular activation of a receptor. However, utilizing cellular fractionation and subcellular localization we also show that PDGFC appears to not only be secreted into the extracellular space, but we also show that PDGFC is also found in the nucleus of breast cancer cell lines. The exact role of nuclear PDGFC is unknown, however, this demonstrates an important shift from the traditional model of growth factors as extracellular effectors to the potential actions of growth factors intracellularly. This may have very important implications clinically. Blocking aberrant growth factors in cancer progression may not be as simple as blocking their actions extracellularly on the receptor. Thus, nuclear localization of growth factors could have important implications in how we understand and target cancer.


Descriptors :   *BREAST CANCER , CELLS(BIOLOGY) , GROWTH(PHYSIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE