Accession Number : ADA612510


Title :   Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Schoepp, Randal J ; Rossi, Cynthia A ; Khan, Sheik H ; Goba, Augustine ; Fair, Joseph N


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a612510.pdf


Report Date : Jul 2014


Pagination or Media Count : 8


Abstract : Sierra Leone in West Africa is in a Lassa fever hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of 500 700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30% 40% of samples tested are positive for Lassa virus (LASV) antigen and/or LASV-specific IgM; thus, 60% 70% of these patients have acute diseases of unknown origin. To investigate what other arthropod- borne and hemorrhagic fever viral diseases might cause serious illness in this region and mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites and LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne and other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, and Marburg viruses but not to Crimean-Congo hemorrhagic fever virus.


Descriptors :   *VIRUS DISEASES , ANTIBODIES , ANTIGENS , ARBOVIRUSES , BLOOD SERUM , CHIKUNGUNYA VIRUS , FEVERS , HEMORRHAGIC FEVERS , ILLNESS , LABORATORIES , PARASITES , PATIENTS , REGIONS , REPRINTS , RIFT VALLEY FEVER , SAMPLING , VIRUSES , WEST AFRICA


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE