Accession Number : ADA610773


Title :   Synthesis and Larvicidal and Adult Topical Activity of Some Hydrazide-Hydrazone Derivatives Against Aedes aegypti


Descriptive Note : Journal article


Corporate Author : NAVY ENTOMOLOGY CENTER OF EXCELLENCE JACKSONVILLE NAS FL


Personal Author(s) : Akdag, Kadriye ; Kocyigit-Kaymakcioglu, Bedia ; Tabanca, Nurhayat ; Ali, Abbas ; Estep, Alden ; Becnel, James J ; Khan, Ikhlas A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a610773.pdf


Report Date : Jan 2014


Pagination or Media Count : 7


Abstract : A series of novel hydrazide-hydrazone derivatives were synthesized and evaluated for their larvicidal and adult topical activity against Aedes aegypti. The proposed structures of all the synthesized compounds were confirmed using elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Compounds 4a-h were screened in larval bioassays at concentrations of 100, 50 and 25 ppm in a dose dependent manner and data for their mortality was recorded. Among the tested compounds, 1-(4-nitrophenyl)-3-(4-{2- oxo-2-[2-(2-oxo-1,2-dihydro-3H-ylidene)hydrazinyl] ethyl} phenyl)urea (4b) showed noteworthy larvacidal activity against Aedes aegypti. Dose-response data of compound 4b showed LC50 and LC90 values of 30.5 (15.4 22.7) and 95.9 (73.8 139.4) ppm, respectively. Screening of compounds 4a-h at four doses by topical bioassay indicated a range of activity between 10000 and 1000 ppm.


Descriptors :   *CULICIDAE , *HYDRAZIDES , *HYDRAZONES , *INSECTICIDES , *SYNTHESIS(CHEMISTRY) , BIOASSAY , DOSAGE , LARVAE , MORTALITY RATE , UREA


Subject Categories : Agricultural Chemistry
      Biology
      Organic Chemistry
      Physical Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE