Accession Number : ADA609498


Title :   Understanding and Targeting Epigenetic Alterations in Acquired Bone Marrow Failure


Descriptive Note : Annual summary rept. 1 May 2012-30 Apr 2014


Corporate Author : MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK


Personal Author(s) : Abdel-Wahab, Omar


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a609498.pdf


Report Date : May 2014


Pagination or Media Count : 31


Abstract : Systematic genomic discovery efforts in patients with bone marrow failure due to myelodysplastic syndrome (MDS) has led to the rapid discovery of recurrent somatic genetic alterations underlying these disorders. Remarkably, a large number of these mutations occur in genes whose function is known, or suspected, to be involved in epigenetic regulation of gene transcription. This includes mutations in ASXL1, TET2, and EZH2. The goals of our proposal were to (1) perform functional genetic characterization of these alterations, (2) determine if these alterations are therapeutically targetable, and (3) perform detailed genomic analysis of specific subsets of MDS patients with no known genetic alterations and with severe bone marrow failure to discover additional genetic alterations contributing to MDS pathogenesis. Since funding of this award we have made major progress in (1) understanding the impact of ASXL1 mutations and loss on chromatin (Abdel- Wahab, et al. Cancer Cell 2012), (2) identifying the in vivo biological effects of deletion of Asxl1 and Tet2 alone and in combination with one another (Abdel- Wahab, et al. J Exp Med 2013), and (3) identified the genome- wide effects of Asxl1 on transcription (Abdel- Wahab, et al. J Exp Med 2013 and Abdel- Wahab, O, et al. Leukemia 2013).


Descriptors :   *BONE MARROW , *GENES , *SIGNS AND SYMPTOMS , FAILURE , GENETICS , GENOME , IN VIVO ANALYSIS , LEUKEMIA , MUTATIONS , PATIENTS , RESPONSE(BIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE