Accession Number : ADA605108


Title :   Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids


Descriptive Note : Journal article


Corporate Author : AGRICULTURAL RESEARCH SERVICE DAWSON GA NATIONAL PEANUT RESEARCH LAB


Personal Author(s) : Sobolev, Victor S ; Khan, Shabana I ; Tabanca, Nurhayat ; Wedge, David E ; Manly, Susan P ; Cutler, Stephen J ; Coy, Monique R ; Becnel, James J ; Neff, Scott A ; Gloer, James B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a605108.pdf


Report Date : 11 Feb 2011


Pagination or Media Count : 11


Abstract : The peanut plant (Arachis hypogaea L.), when infected by a microbial pathogen, is capable of producing stilbenederived compounds that are considered antifungal phytoalexins. In addition, the potential health benefits of other stilbenoids from peanuts, including resveratrol and pterostilbene, have been acknowledged by several investigators. Despite considerable progress in peanut research, relatively little is known about the biological activity of the stilbenoid phytoalexins. This study investigated the activities of some of these compounds in a broad spectrumof biological assays. Since peanut stilbenoids appear to play roles in plant defense mechanisms, they were evaluated for their effects on economically important plant pathogenic fungi of the genera Colletotrichum, Botrytis, Fusarium, and Phomopsis. We further investigated these peanut phytoalexins, together with some related natural and synthetic stilbenoids (a total of 24 compounds) in a panel of bioassays to determine their anti-inflammatory, cytotoxic and antioxidant activities in mammalian cells. Several of these compounds were also evaluated as mammalian opioid receptor competitive antagonists. Assays for adult mosquito and larvae toxicity were also performed. The results of these studies reveal that peanut stilbenoids, as well as related natural and synthetic stilbene derivatives, display a diverse range of biological activities.


Descriptors :   *ANTIOXIDANTS , *PEANUT OIL , *STILBENES , ASSAYING , BENEFITS , BIOLOGY , CELLS , CULICIDAE , CYTOTOXINS , HEALTH , LARVAE , MICROORGANISMS , REPRINTS , TOXICITY


Subject Categories : Agronomy, Horticulture and Aquiculture
      Food, Food Service and Nutrition


Distribution Statement : APPROVED FOR PUBLIC RELEASE