Accession Number : ADA604752


Title :   Serotonin Signal Transduction in Two Groups of Autistic Patients


Descriptive Note : Final rept. 15 Sep 2011-14 Sep 2013


Corporate Author : ILLINOIS UNIV AT CHICAGO


Personal Author(s) : Rasenick, Mark M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a604752.pdf


Report Date : Dec 2013


Pagination or Media Count : 7


Abstract : The most significant findings during the period of this project were the discovery that lymphoblasts from autistic subjects could be used to determine overall neurotransmitter responsiveness. We had predicted that cells from autistic subjects would sort out, particularly in the arena of serotonin sensitivity, from those cells obtained from autistic subjects with normal serum serotonin. This was not the case, as the sequellae of events following serotonin binding to 5HT1, 5HT2 or 5HT4,7 receptors was identical in cells from the high and low serotonin autistic subjects. However, particularly for 5HT1 signaling, both autistic groups handily separated from the control. Thus, it appears that we have developed a cultured cell system that is both easy to manipulate and useful for studying serotonin signaling in autism.


Descriptors :   *MENTAL DISORDERS , *NEUROCHEMISTRY , BEHAVIOR , BLOOD SERUM , NEUROTRANSMITTERS , PATIENTS , PROTEINS , SENSITIVITY , SEROTONIN , SIGNALS


Subject Categories : Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE