Accession Number : ADA603854


Title :   Understanding the Function of Tuberous Sclerosis Complex Genes in Neural Development: Roles in Synapse Assembly and Axon Guidance


Descriptive Note : Final rept. 1 Jul 2007-30 Nov 2011


Corporate Author : PENNSYLVANIA STATE UNIV STATE COLLEGE


Personal Author(s) : Selleck, Scott B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a603854.pdf


Report Date : Feb 2012


Pagination or Media Count : 64


Abstract : The goal of our project was to use the fruitfly Drosophila melanogaster, to identify molecular mechanisms affecting nervous system development and behavior that occur as a consequence of Tsc-Tor-Rheb signaling disruption, mimicking the types of changes that are known to occur in human patients with tuberous sclerosis. In our first manuscript we established that hyperactivity of the Tor pathway had several important neurodevelopmental consequences, including misrouting of axon guidance in the visual system and synapse overgrowth at the neuromuscular junction. We showed that synapse overgrowth mediated by Rheb was insensitive to rapamycin, a Tor Complex 1 inhibitor, suggesting that other Torcontaining complexes mediate these changes in synapse function.


Descriptors :   *NERVOUS SYSTEM , BEHAVIOR , DROSOPHILA , GUIDANCE , HUMANS , INHIBITORS , MOLECULAR PROPERTIES , NERVE FIBERS , PATIENTS , SENSITIVITY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE