Accession Number : ADA603587


Title :   Learning and Olfaction: Understanding and Enhancing a Critical Information Channel


Descriptive Note : Final rept. 15 Feb 2011-14 Feb 2013


Corporate Author : MONELL CHEMICAL SENSES CENTER PHILADELPHIA PA


Personal Author(s) : Gelperin, Alan ; Beauchamp, Gary ; Cowart, Beverly ; Dalton, Pam ; Lowe, Graeme ; Lundstrom, Johan ; Preti, George ; Reisert, Johannes ; Wysocki, Charles ; Yamazaki, Kunio


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a603587.pdf


Report Date : 13 May 2013


Pagination or Media Count : 68


Abstract : This research program consisted of nine interacting projects directed by ten Principal Investigators. The overarching goal of the program was to understand how experience and learning influence olfactory functioning at the molecular, cellular, neural and behavioral levels. Four of the projects used genetically engineered mouse models to investigate basic olfactory mechanisms. Five complimentary projects focused on olfactory processing in humans. Techniques employed included sophisticated brain imagining in both animal models and humans, use of state-of-the-art psychophysiological measures of arousal and emotion, and a variety of behavioral paradigms. Results, described in detail in individual reports, included new insights into physiological, neural and psychological mechanisms underlying olfactory learning and the role of learning and stress in human odor production and response. These results have relevance to both basic understanding of olfaction and to practical issues such as those related to ameliorating post traumatic stress disorder, olfactory loss due to traumatic brain injury or exposure to toxic volatile chemicals. The program also included a seminar program focused on the common interests of the ARO-supported research team and a one day symposium on olfaction and learning that brought 7 outstanding outside investigators to Monell to interact with Monell PIs, staff and ARO representatives.


Descriptors :   *ANIMALS , *HUMANS , *LEARNING , *SMELL , BEHAVIOR , EXPOSURE(GENERAL) , MICE , MOLECULES , ODORS , PSYCHOPHYSIOLOGY , STRESSES


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE