Accession Number : ADA602407


Title :   Design and Synthesis of Bifunctional Oxime Reactivators of OP- inhibited Cholinesterase


Descriptive Note : Annual rept. 8 Aug 2012-7 Aug 2013


Corporate Author : DELAWARE UNIV NEWARK


Personal Author(s) : Koh, John T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a602407.pdf


Report Date : Aug 2013


Pagination or Media Count : 32


Abstract : Organophosphorous (OP) cholinesterase inhibitors remain a significant threat to military and civilian personnel. Reactivators of OP inhibited cholinesterases can serve as OP agent antidotes but can be limited by their poor bioavailability and poor reactivation kinetics. New reactivator designs may be able to address these shortcomings. This proposal explores and evaluates the feasibly of synthesizing two new classes of oxime reactivators that use bifunctional catalysis to enhance kinetics and improve bioavailability. The synthesis of amino-functionalized aryltrifulorketoxmines and 3-alkylaminopyridinium oximes are described.


Descriptors :   *ACETYLCHOLINESTERASE , *CHOLINESTERASE INHIBITORS , *ORGANOPHOSPHATES , ANTIDOTES , CATALYSIS , CIVILIAN PERSONNEL , MILITARY PERSONNEL , ORGANIC PHOSPHORUS COMPOUNDS , OXIMES , SYNTHESIS(CHEMISTRY)


Subject Categories : Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE