Accession Number : ADA598532


Title :   Systems Biology Approaches for Discovering Biomarkers for Traumatic Brain Injury


Descriptive Note : Journal article


Corporate Author : BIOTECHNOLOGY HIGH PERFORMANCE COMPUTING SOFTWARE APPLICATIONS INST FREDERICK MD


Personal Author(s) : Feala, Jacob D ; AbdulHameed, Mohamed D ; Yu, Chenggang ; Dutta, Bhaskar ; Yu, Xueping ; Schmid, Kara ; Dave, Jitendra ; Tortella, Frank ; Reifman, Jaques


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a598532.pdf


Report Date : 01 Jul 2013


Pagination or Media Count : 17


Abstract : The rate of traumatic brain injury (TBI) in service members with wartime injuries has risen rapidly in recent years, and complex, variable links have emerged between TBI and long-term neurological disorders. The multifactorial nature of TBI secondary cellular response has confounded attempts to find cellular biomarkers for its diagnosis and prognosis or for guiding therapy for brain injury. One possibility is to apply emerging systems biology strategies to holistically probe and analyze the complex interweaving molecular pathways and networks that mediate the secondary cellular response through computational models that integrate these diverse data sets. Here, we review available systems biology strategies, databases, and tools. In addition, we describe opportunities for applying this methodology to existing TBI data sets to identify new biomarker candidates and gain insights about the underlying molecular mechanisms of TBI response. As an exemplar, we apply network and pathway analysis to a manually compiled list of 32 protein biomarker candidates from the literature, recover known TBI-related mechanisms, and generate hypothetical new biomarker candidates.


Descriptors :   *MOLECULES , *PROTEINS , *SYSTEMS BIOLOGY , *TRAUMATIC BRAIN INJURIES , DATA BASES , GENES , INTERACTIONS


Subject Categories : Genetic Engineering and Molecular Biology
      Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE