Accession Number : ADA595854


Title :   Hydroprocessed Esters and Fatty Acids (HEFA) Bio-Based Jet Fuels: Sensory Irritation Study and Human Health Hazard Assessment


Descriptive Note : Interim rept. Jan 2011-Jun 2012


Corporate Author : AIR FORCE RESEARCH LAB BROOKS CITY BASE TX HUMAN EFFECTIVENESS DIRECTORATE DIRECTED ENERGY BIOEFFECTS DIVISION/ OPTICAL RADIATION BRANCH


Personal Author(s) : Sterner, Teresa R ; Sweeney, Lisa M ; Mumy, Karen L ; Wong, Brian A ; James, R A ; Reboulet, James ; Sharits, Brian ; Grimm, Michael ; Gargas, Nathan ; Striebich, Richard C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a595854.pdf


Report Date : 30 Jun 2013


Pagination or Media Count : 110


Abstract : The purpose of this technical report is two-fold. First, this technical report presents the results of a sensory irritation assay conducted in male Swiss-Webster mice exposed to different concentrations of hydroprocessed esters and fatty acids (HEFA) bio-based jet fuels, HEFA-Camelina (HEFA-C) and HEFA-Tallow (HEFA-T). The mice were exposed via a modified nose-only plethysmograph tube to each fuel, administered as an aerosol/vapor combination. For HEFA-C, the predicted RD50 (50 percent reduction in respiratory rate) was greater than 11,755 mg/m3. For HEFA-T, the predicted RD50 was greater than 13,306 mg/m3. This technical report also summarizes toxicity data for HEFA fuels, including HEFA-C, HEFA-T and a HEFA fuel with a feedstock of mixed animal fats and oils (HEFA-F). HEFA toxicity data are then compared with toxicity data from synthetic paraffinic kerosene (SPK) alternative jet fuel and petroleum derived JP-8. The toxicity data are used to develop a comparative occupational exposure limit (OEL) for HEFA fuels that concurs with the current JP-8 OEL (200 mg/m3).


Descriptors :   *EXPOSURE(PHYSIOLOGY) , *FATTY ACID ESTERS , *JET ENGINE FUELS , ASSAYING , GENOTOXICITY , HAZARDS , INHALATION , IRRITATION , KEROSENE , MUTAGENS , TOXICITY , TOXICOLOGY


Subject Categories : Biochemistry
      Anatomy and Physiology
      Toxicology
      Fuels


Distribution Statement : APPROVED FOR PUBLIC RELEASE