Accession Number : ADA595285


Title :   Role of Natural Killer T Cells in Immunogenic Chemotherapy for Breast Cancer


Descriptive Note : Annual summary rept. 1 Sep 2012-31 Aug 2013


Corporate Author : MELBOURNE UNIV PARKVILLE (AUSTRALIA)


Personal Author(s) : Paget, Christophe ; Duret, Helene ; Smyth, Mark J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a595285.pdf


Report Date : Sep 2013


Pagination or Media Count : 58


Abstract : During this second year of investigation, we have confirmed the important role of gamma delta T cells in the efficacy of immunogenic chemotherapy using anthracyclines. In the meantime, the NKT cells seem to be dispensable for this effect at least in this particular situation. Moreover, we have also identified a population of gamma delta T cells with a unique phenotype never described before (CD3bright). Interestingly, this population has a clear intrinsic ability to produce IL-17 compared to any other gamma delta T cells and are represented at a high frequency in breast cancer tumor environment. We have highlighted several key homeostatic factors on this population and identified their precise phenotype. Of interest a human gamma delta T cell population display a similar phenotype (CD3bright) with gamma delta T17-like cell hallmarks. Our future efforts will focus on this population and their putative role in immunogenic chemotherapy for breast cancer.


Descriptors :   *BREAST CANCER , *CHEMOTHERAPY , *THERAPY , CELLS(BIOLOGY) , GAMMA RAYS , HIGH FREQUENCY , HOMEOSTASIS , POPULATION , T LYMPHOCYTES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE