Accession Number : ADA594061


Title :   GP140/CDCPI in the Development of Prostate Cancer Metastasis


Descriptive Note : Final rept. 1 May 2008-31 Aug 2013


Corporate Author : CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA


Personal Author(s) : Knudsen, Beatrice


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a594061.pdf


Report Date : Sep 2013


Pagination or Media Count : 20


Abstract : The purpose of the research is to analyze the expression and function of gp140/CDCP1, a regulator of SRC kinase activity in prostate cancer. The scope of the project in year 3 is to determine expression in tissues from patients. The main results are from immunohistochemical analyses of gp140 in normal prostate epithelium, primary prostate cancer and metastatic prostate cancer. Gp140 RNA expression and protein membrane expression, but not total protein expression, are significantly decreased in primary cancers compared to normal epithelium. In metastatic disease, total gp140 protein expression decreases and is significantly lower in bone compared to soft tissue metastases. Overall, gp140 expression decreases during metastatic progression, supporting the concept that the loss of gp140 facilitates tumor metastasis.


Descriptors :   *PROSTATE CANCER , BONES , EPITHELIUM , IMMUNOLOGY , METASTASIS , PHOSPHORUS TRANSFERASES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE