Accession Number : ADA593238


Title :   PCBs Alter Dopamine Mediated Function in Aging Workers


Descriptive Note : Final rept. 15 Dec 2001-14 Dec 2010


Corporate Author : HEALTH RESEARCH INC MENANDS NY


Personal Author(s) : Seegal, Richard F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a593238.pdf


Report Date : Jan 2011


Pagination or Media Count : 47


Abstract : We hypothesized that occupational exposure to polychlorinated biphenyls (PCBs) reduces dopamine (DA) terminal densities in the basal ganglia. We found, using beta-CIT imaging, a significant negative relationship between current serum PCB concentrations and the density of beta-CIT binding only in women. We also determined that bone lead, measured using XRF fluorescent techniques, is associated with greater decrements in memory, executive function and motor function in women compared to similarly aged men with similar bone lead levels. These latter findings are the first to demonstrate a sexual dimorphism in these behaviors associated with low to moderate bone lead concentrations. We are writing a manuscript describing changes in these behaviors with bone lead and have previously published two manuscripts describing: (i) the effects of PCB exposure on beta-CIT and (ii) the half lives of PCB congeners over a 28 year interval.


Descriptors :   *DOPAMINE , *PARKINSONS DISEASE , *POLYCHLORINATED BIPHENYLS , AGING(PHYSIOLOGY) , BEHAVIOR , BIPHENYL , BLOOD SERUM , BONES , DEGRADATION , EXPOSURE(PHYSIOLOGY) , GANGLIA , INTERVALS , LEAD(METAL) , OCCUPATIONAL MEDICINE


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE