Accession Number : ADA593230


Title :   Mission Connect Mild TBI Translational Research Consortium


Descriptive Note : Final rept. 1 Aug 2008-31 Jul 2013


Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON


Personal Author(s) : Narayana, Ponnada A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a593230.pdf


Report Date : Aug 2013


Pagination or Media Count : 23


Abstract : Both human and animal MRI scans were performed as a part of specific aims 1 and 2. Two types of animal studies were performed. In the first study we investigated the effect of hemorrhagic shock on animals with traumatic injury. In the second study we investigated the neuroprotective effects of Epo on the injury outcome. In humans MRI data were acquired on both orthopedic controls and mTBI subjects at baselone (within 24 hours after injury) and at three months. The multi-modal MRI measures included include regional and global volumetry using tensor-based morphometry, tissue microstructural integrity using diffusion tensor imaging (DTI), and T2-weighted images for lesion volumes in animals, and magnetic resonance spectroscopy (MRS) for investigating the metabolic changes, and magnetization transfer imaging (MTR) for assessing the state of myelin (only in humans). In animals with hemorrhagic shock, significant atrophy was detected in some gray matter structures, including the ipsilateral parietal cortex and parts of amygdaloid nucleus and suprachiasmatic nucleus away from the injury site. Significant reduction in FA in the white matter tracts closest to site of injury: ipsilateral external capsule, internal capsule, splenium, body and genu of corpus callosum were also observed. Based on MRS, Epo appears to show some neuroprotective effect. In humans, mean diffusivity (MD), based on DTI, showed group differences between orthopedic controls and mTBI subjects at baseline. These differences appear to resolve on the month 3 scans. We did not observe any group differences on any of the other MRI measures. These studies resulted in two abstract and one publication. Two more manuscripts are under preparation.


Descriptors :   *HEMORRHAGIC SHOCK , *MAGNETIC RESONANCE IMAGING , *TRAUMATIC BRAIN INJURIES , BASE LINES , CONTROL , HUMANS , IMAGES , LESIONS , MAGNETIC RESONANCE , MAGNETIZATION , MISSIONS , MULTIMODE , NUCLEI , ORTHOPEDICS , REDUCTION , SCANNING , SPECTROSCOPY , STRUCTURES , TENSORS , TRAUMA , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE