Accession Number : ADA592920


Title :   Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury


Descriptive Note : Annual rept. 30 Sep 2012-29 Sep 2013


Corporate Author : STATE UNIV OF NEW YORK DOWNSTATE MEDICAL CENTER BROOKLYN


Personal Author(s) : Bergold, Peter


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a592920.pdf


Report Date : Oct 2013


Pagination or Media Count : 26


Abstract : Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Three tasks will be done to achieve this objective: 1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following closed head injury in mice (CHI). 2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3) A restoration of cognitive function will be tested three months after CHI. The grantee has shown that MINO plus NAC improves cognition in two models of TBI, a single impact closed head injury (CHI) in mice and the CCI model in rats. The drug combination improves cognition and limits white matter injury in two models and two species. These data attest to the potency of the drug combination.


Descriptors :   *TRAUMATIC BRAIN INJURIES , BEHAVIOR , COGNITION , DOSAGE , DRUGS , HEAD(ANATOMY) , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE