Accession Number : ADA591986


Title :   Novel Probiotic Therapies for Autism


Descriptive Note : Annual rept. 22 Aug 2012-21 Aug 2013


Corporate Author : CALIFORNIA INST OF TECH PASADENA


Personal Author(s) : Patterson, Paul H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a591986.pdf


Report Date : Sep 2013


Pagination or Media Count : 10


Abstract : Although autism spectrum disorder (ASD) is defined by core behavioral impairments, gastrointestinal (GI) symptoms are commonly reported. Subsets of ASD individuals display dysbiosis of the gut microbiome, and some exhibit increased intestinal permeability. We demonstrate GI barrier defects in a mouse model of an important ASD risk factor, maternal immune activation (MIA). Remarkably, oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. MIA offspring also display an altered serum metabolomic profile, and B. fragilis normalizes levels of several of the serum metabolites. These findings suggest a gut-microbiome-brain connection in autism, and identify a potential probiotic therapy for ASD. We have now developed assays for some of these serum metabolites and are beginning to assay them in ASD serum samples


Descriptors :   *MENTAL DISORDERS , *SIGNS AND SYMPTOMS , ANATOMICAL MODELS , BACTEROIDES , BARRIERS , BEHAVIORAL SCIENCES , BLOOD SERUM , FEMALES , GASTROINTESTINAL SYSTEM , HUMANS , IMMUNITY , INTESTINES , METABOLITES , ORAL INTAKE , ORDER DISORDER TRANSFORMATIONS , PREGNANCY


Subject Categories : Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE